Cheapest one-way flights from Panama City to Madrid in December from $449

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

01 Dec Turkish Airlines
08 Dec Turkish Airlines
06 Dec Turkish Airlines
07 Dec Turkish Airlines
09 Dec Turkish Airlines
18 Dec Wingo
01 Dec Air Europa direct
17 Dec Avianca
07 Dec Air Europa direct
08 Dec Air Europa direct

Also check the deals for return flights from Panama City to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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