Cheapest return flights from Panama City to Madrid in December from $749

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

Return flights

24 Dec - 12 Jan KLM
27 Dec - 25 Jan Air France
08 Dec - 02 Jan Air France
27 Dec - 25 Jan Air Europa direct
01 Dec - 18 Dec Iberia
01 Dec - 14 Dec Iberia
23 Dec - 12 Jan KLM
20 Dec - 20 Jan KLM
16 Dec - 05 Jan Air France
07 Dec - 12 Dec Turkish Airlines
07 Dec - 12 Dec Air Europa direct
17 Dec - 29 Dec Iberia direct
24 Dec - 12 Jan Iberia direct
20 Dec - 10 Jan Iberia direct
19 Dec - 04 Jan KLM
10 Dec - 17 Dec Iberia direct
01 Dec - 13 Dec Air France

Also check the deals for one-way flights from Panama City to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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