Cheapest return flights from Panama City to Madrid in December from $693

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

Return flights

05 Dec - 12 Dec Air Europa direct
01 Dec - 17 Jan Air Europa direct
13 Dec - 13 Jan Air Europa direct
24 Dec - 06 Jan Air France
05 Dec - 03 Jan Avianca
08 Dec - 11 Dec Air Europa direct
24 Dec - 31 Dec Air France
14 Dec - 24 Dec Air Europa direct
09 Dec - 24 Dec Air Europa direct
06 Dec - 07 Jan Air France
22 Dec - 19 Jan Air France
08 Dec - 02 Jan Turkish Airlines
31 Dec - 16 Jan Air Europa direct
06 Dec - 07 Jan Air Europa direct
08 Dec - 02 Jan Air Europa direct
24 Dec - 31 Dec Air Europa direct
11 Dec - 24 Dec Air Europa direct
08 Dec - 23 Dec Iberia
17 Dec - 24 Dec Air Europa direct
17 Dec - 31 Dec Air Europa direct

Also check the deals for one-way flights from Panama City to Madrid in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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