Cheapest return flights from Panama City to Madrid in December from $675

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

Return flights

31 Dec - 27 Jan Avianca
01 Dec - 07 Dec Turkish Airlines
29 Dec - 20 Jan Air France
02 Dec - 18 Jan Air France
27 Dec - 29 Jan Air France
09 Dec - 16 Jan Avianca
11 Dec - 20 Jan Avianca
14 Dec - 16 Jan Avianca
02 Dec - 16 Jan Avianca
01 Dec - 17 Jan Avianca
31 Dec - 27 Jan Air Europa direct
01 Dec - 11 Dec Iberia
06 Dec - 13 Dec United
04 Dec - 11 Dec United
03 Dec - 08 Dec Iberia direct
16 Dec - 31 Dec Air France
04 Dec - 28 Dec Air France
01 Dec - 24 Dec Air France
05 Dec - 12 Dec Air Europa direct
01 Dec - 15 Dec United

Also check the deals for one-way flights from Panama City to Madrid in December.

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