Cheapest return flights from Panama City to Madrid in December from $724

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in December 2025 (see full year).

Return flights

31 Dec - 27 Jan Air Europa direct
27 Dec - 27 Jan Air France
31 Dec - 20 Jan Avianca
24 Dec - 20 Jan KLM
27 Dec - 27 Jan Air Europa direct
25 Dec - 25 Jan KLM
24 Dec - 19 Jan Air Europa direct
28 Dec - 22 Jan Air Europa direct
26 Dec - 31 Jan KLM
31 Dec - 14 Jan Air Europa direct
24 Dec - 30 Dec KLM
16 Dec - 31 Dec Air France
25 Dec - 29 Dec KLM
24 Dec - 29 Dec Iberia direct
22 Dec - 31 Dec Air France
16 Dec - 30 Dec Air France
24 Dec - 30 Dec Air Europa direct
24 Dec - 28 Dec Iberia
14 Dec - 18 Dec Iberia
26 Dec - 30 Dec Air France

Also check the deals for one-way flights from Panama City to Madrid in December.

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