Cheapest one-way flights from Panama City to Madrid in April from $567

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in April 2026 (see full year).

One-Way flights

11 Apr Wingo
24 Apr Avianca
19 Apr Avianca
19 Apr Air Europa direct
11 Apr Air Europa direct
07 Apr Air Europa direct
04 Apr Avianca
24 Apr Air Europa direct
04 Apr Air Europa direct
15 Apr Air Europa direct

Also check the deals for return flights from Panama City to Madrid in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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