Cheapest return flights from Panama City to Madrid in April from $682

AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in April 2026 (see full year).

Return flights

17 Apr - 30 Apr Air France
15 Apr - 25 Apr Air France
10 Apr - 19 Apr Air France
22 Apr - 02 May Air France
22 Apr - 22 May Air France
17 Apr - 01 May Air France
01 Apr - 14 Apr Avianca
17 Apr - 01 May Air Europa direct
20 Apr - 29 Apr Air Europa direct
22 Apr - 22 May Air Europa direct
22 Apr - 02 May Air Europa direct
25 Apr - 03 May Air Europa direct
14 Apr - 21 Apr Air Europa direct
22 Apr - 29 Apr Air Europa direct
13 Apr - 02 May Air Europa direct
23 Apr - 04 May Air Europa direct
30 Apr - 11 May Air Europa direct
15 Apr - 25 Apr Air Europa direct
01 Apr - 12 Apr Air France
01 Apr - 19 Apr Air France

Also check the deals for one-way flights from Panama City to Madrid in April.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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