Cheapest one-way flights from Panama City to Madrid in September from $435

Best time to book flights for Panama City (PTY) to Madrid (MAD) flights at AirHint

AirHint found the following cheapest one-way flights from Panama City (PTY) to Madrid (MAD) in September 2025 (see full year).

One-Way flights

19 Sep Turkish Airlines
07 Sep Turkish Airlines
10 Sep Turkish Airlines
14 Sep Turkish Airlines
17 Sep Turkish Airlines
21 Sep Turkish Airlines
16 Sep Turkish Airlines
15 Sep Turkish Airlines
20 Sep Copa
18 Sep Avianca

Also check the deals for return flights from Panama City to Madrid in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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