AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in September 2025 (see full year).

Return flights

19 Sep - 22 Sep	Air France
12 Sep - 18 Sep	Air France
10 Sep - 20 Sep	Air France
10 Sep - 16 Sep	Air France
12 Sep - 24 Sep	Air France
19 Sep - 24 Sep	Air France
14 Sep - 25 Sep	Turkish Airlines
07 Sep - 16 Sep	Air France
12 Sep - 19 Sep	Air France
12 Sep - 20 Sep	Air France
24 Sep - 18 Oct	Turkish Airlines
19 Sep - 14 Oct	Turkish Airlines
28 Sep - 04 Oct	Turkish Airlines
30 Sep - 13 Oct	Avianca
19 Sep - 06 Oct	Iberia	direct
19 Sep - 14 Oct	Iberia	direct
30 Sep - 14 Oct	Avianca
30 Sep - 07 Oct	Avianca
28 Sep - 05 Oct	Air France
29 Sep - 26 Oct	Avianca

Also check the deals for one-way flights from Panama City to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Madrid in September from $723

Return flights