AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in September 2025 (see full year).

Return flights

28 Sep - 04 Oct	Turkish Airlines
12 Sep - 26 Sep	Air France
10 Sep - 18 Sep	Air France
10 Sep - 19 Sep	Air France
10 Sep - 26 Sep	Air France
10 Sep - 14 Sep	Air France
25 Sep - 05 Oct	Air Europa	direct
10 Sep - 24 Sep	Air France
26 Sep - 12 Oct	Air Europa	direct
21 Sep - 30 Oct	Air Europa	direct
10 Sep - 31 Oct	Turkish Airlines
08 Sep - 17 Sep	Air France
08 Sep - 19 Sep	Air France
23 Sep - 01 Oct	Air Europa	direct
30 Sep - 14 Oct	Air France
20 Sep - 11 Oct	Air Europa	direct
14 Sep - 24 Sep	Turkish Airlines
10 Sep - 21 Sep	Air France
22 Sep - 01 Oct	Air Europa	direct
08 Sep - 07 Oct	Iberia	direct

Also check the deals for one-way flights from Panama City to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Madrid in September from $719

Return flights