AirHint found the following cheapest return flights from Panama City (PTY) to Madrid (MAD) in September 2026 (see full year).

Return flights

27 Sep - 10 Oct	Air Europa	direct
30 Sep - 07 Oct	Air Europa	direct
13 Sep - 23 Sep	Iberia	direct
19 Sep - 27 Sep	Air France
19 Sep - 26 Sep	Air France
14 Sep - 25 Sep	Air France
14 Sep - 25 Sep	Air Europa	direct
19 Sep - 27 Sep	Air Europa	direct
19 Sep - 26 Sep	Air Europa	direct

Also check the deals for one-way flights from Panama City to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Madrid in September from $725

Return flights