Cheapest one-way flights from Santiago to La Serena in December from $25

AirHint found the following cheapest one-way flights from Santiago (SCL) to La Serena (LSC) in December 2025 (see full year).

One-Way flights

22 Dec Sky Airline direct
25 Dec Sky Airline direct
29 Dec Sky Airline direct
21 Dec LATAM Airlines Group direct
28 Dec LATAM Airlines Group direct
27 Dec Sky Airline direct
16 Dec Sky Airline direct
17 Dec Sky Airline direct
18 Dec LATAM Airlines Group direct
30 Dec LATAM Airlines Group direct

Also check the deals for return flights from Santiago to La Serena in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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