Cheapest one-way flights from Santiago to La Serena in December from $26

AirHint found the following cheapest one-way flights from Santiago (SCL) to La Serena (LSC) in December 2025 (see full year).

One-Way flights

17 Dec LATAM Airlines Group direct
07 Dec LATAM Airlines Group direct
22 Dec JetSmart direct
25 Dec LATAM Airlines Group direct
06 Dec JetSmart direct
24 Dec LATAM Airlines Group direct

Also check the deals for return flights from Santiago to La Serena in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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