Cheapest one-way flights from Santiago to Mexico City in December from $297

Best time to book flights for Santiago (SCL) to Mexico City (MEX) flights at AirHint

AirHint found the following cheapest one-way flights from Santiago (SCL) to Mexico City (MEX) in December 2025 (see full year).

One-Way flights

30 Dec JetSmart
22 Dec Sky Airline
27 Dec Sky Airline
21 Dec Sky Airline
30 Dec LATAM Airlines Group direct
21 Dec Aeromexico direct
22 Dec Aeromexico direct
27 Dec LATAM Airlines Group direct
20 Dec Copa

Also check the deals for return flights from Santiago to Mexico City in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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