AirHint found the following cheapest one-way flights from Santo Domingo (SDQ) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

06 Dec	WORLD2FLY	direct
11 Dec	WORLD2FLY	direct
10 Dec	Arajet
08 Dec	Spirit Airlines
12 Dec	Spirit Airlines
15 Dec	Spirit Airlines
31 Dec	Arajet
27 Dec	WORLD2FLY	direct
20 Dec	WORLD2FLY	direct
29 Dec	Arajet

Also check the deals for return flights from Santo Domingo to Madrid in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Santo Domingo to Madrid in December from $297

One-Way flights