AirHint found the following cheapest return flights from Santo Domingo (SDQ) to Madrid (MAD) in December 2025 (see full year).

Return flights

03 Dec - 10 Dec	Arajet
10 Dec - 10 Jan	Arajet
04 Dec - 10 Dec	Arajet
05 Dec - 10 Dec	Arajet
01 Dec - 06 Jan	Arajet
20 Dec - 11 Jan	WORLD2FLY	direct
18 Dec - 26 Jan	Iberia	direct
28 Dec - 17 Jan	Iberia	direct
20 Dec - 02 Jan	Iberia	direct
26 Dec - 04 Jan	Iberia	direct
01 Dec - 06 Jan	Iberia	direct
08 Dec - 13 Jan	Air Europa	direct
05 Dec - 10 Dec	Air Europa	direct
03 Dec - 10 Dec	Air Europa	direct
19 Dec - 28 Dec	Iberia	direct
04 Dec - 10 Dec	Air Europa	direct
26 Dec - 28 Dec	KLM
26 Dec - 28 Dec	Iberia	direct

Also check the deals for one-way flights from Santo Domingo to Madrid in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santo Domingo to Madrid in December from $655

Return flights