Cheapest one-way flights from Santo Domingo to Panama City in December from $244

AirHint found the following cheapest one-way flights from Santo Domingo (SDQ) to Panama City (PTY) in December 2025 (see full year).

One-Way flights

24 Dec Avianca
30 Dec Avianca
15 Dec Arajet
17 Dec Arajet
12 Dec Copa direct
15 Dec Copa direct
27 Dec Copa direct
30 Dec Copa direct
31 Dec Copa direct
23 Dec Copa direct

Also check the deals for return flights from Santo Domingo to Panama City in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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