AirHint found the following cheapest return flights from Guayaquil (GYE) to Santiago (SCL) in December 2025 (see full year).

Return flights

26 Dec - 01 Jan	Avianca
27 Dec - 01 Jan	Avianca
21 Dec - 28 Dec	Avianca
26 Dec - 30 Dec	Avianca
25 Dec - 30 Dec	Avianca
24 Dec - 28 Dec	Avianca
18 Dec - 25 Dec	Avianca
01 Dec - 08 Dec	Avianca
10 Dec - 14 Dec	Avianca
20 Dec - 24 Dec	Avianca
24 Dec - 27 Dec	Avianca
28 Dec - 11 Jan	Avianca
22 Dec - 29 Dec	Avianca
21 Dec - 07 Jan	Avianca
05 Dec - 06 Jan	Avianca
18 Dec - 05 Jan	Avianca
30 Dec - 06 Jan	Avianca
20 Dec - 05 Jan	Avianca
23 Dec - 05 Jan	Avianca
24 Dec - 05 Jan	Avianca

Also check the deals for one-way flights from Guayaquil to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Santiago in December from $399

Return flights