Cheapest return flights from Guayaquil to Santiago in September from $328

AirHint found the following cheapest return flights from Guayaquil (GYE) to Santiago (SCL) in September 2025 (see full year).

Return flights

14 Sep - 26 Sep Avianca
14 Sep - 21 Sep Avianca
30 Sep - 07 Oct LATAM Airlines Group
30 Sep - 28 Oct LATAM Airlines Group
12 Sep - 21 Sep Copa
11 Sep - 20 Sep Copa
10 Sep - 20 Sep Copa
12 Sep - 19 Sep Copa
10 Sep - 18 Sep Copa
09 Sep - 20 Sep LATAM Airlines Group
10 Sep - 25 Sep Copa
08 Sep - 19 Sep Copa
18 Sep - 03 Oct LATAM Airlines Group
18 Sep - 02 Oct LATAM Airlines Group

Also check the deals for one-way flights from Guayaquil to Santiago in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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