AirHint found the following cheapest return flights from Istanbul (IST) to San Francisco (SFO) in December 2025 (see full year).

Return flights

03 Dec - 08 Dec	KLM
02 Dec - 08 Dec	KLM
12 Dec - 08 Jan	KLM
02 Dec - 09 Dec	KLM
24 Dec - 14 Jan	KLM
25 Dec - 13 Jan	KLM
24 Dec - 21 Jan	KLM
25 Dec - 08 Jan	KLM
14 Dec - 15 Jan	KLM
23 Dec - 08 Jan	KLM
24 Dec - 09 Jan	KLM
25 Dec - 09 Jan	KLM
23 Dec - 30 Dec	KLM
25 Dec - 29 Jan	KLM
16 Dec - 30 Dec	Air France
25 Dec - 28 Dec	KLM
04 Dec - 10 Dec	Lufthansa
02 Dec - 10 Dec	Lufthansa
21 Dec - 28 Dec	KLM
03 Dec - 11 Dec	Delta

Also check the deals for one-way flights from Istanbul to San Francisco in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in San Francisco

Cheap car rent in San Francisco

Cheapest return flights from Istanbul to San Francisco in December from $510

Return flights