AirHint found the following cheapest return flights from Istanbul (IST) to San Francisco (SFO) in December 2025 (see full year).

Return flights

06 Dec - 29 Jan	KLM
11 Dec - 14 Jan	KLM
24 Dec - 30 Dec	KLM
22 Dec - 29 Dec	Air France
02 Dec - 14 Dec	British Airways
21 Dec - 27 Dec	British Airways
11 Dec - 14 Jan	Turkish Airlines	direct
06 Dec - 29 Jan	Turkish Airlines	direct
22 Dec - 29 Dec	Turkish Airlines	direct
24 Dec - 30 Dec	Turkish Airlines	direct
21 Dec - 27 Dec	Turkish Airlines	direct
02 Dec - 14 Dec	Turkish Airlines	direct

Also check the deals for one-way flights from Istanbul to San Francisco in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to San Francisco in December from $486

Return flights