AirHint found the following cheapest return flights from Los Angeles (LAX) to Santiago (SCL) in September 2025 (see full year).

Return flights

11 Sep - 22 Sep	Spirit Airlines
01 Sep - 08 Sep	Avianca
12 Sep - 23 Sep	Spirit Airlines
06 Sep - 20 Sep	Avianca
01 Sep - 29 Sep	Frontier Airlines
25 Sep - 29 Sep	Spirit Airlines
19 Sep - 17 Oct	Copa
14 Sep - 25 Sep	LATAM Airlines Group
11 Sep - 22 Sep	LATAM Airlines Group	direct
06 Sep - 20 Sep	LATAM Airlines Group	direct
12 Sep - 23 Sep	LATAM Airlines Group	direct
20 Sep - 18 Oct	Copa
20 Sep - 18 Oct	LATAM Airlines Group	direct

Also check the deals for one-way flights from Los Angeles to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Los Angeles to Santiago in September from $685

Return flights