AirHint found the following cheapest return flights from Lisbon (LIS) to Santiago (SCL) in December 2025 (see full year).

Return flights

02 Dec - 09 Dec	LATAM Airlines Group
03 Dec - 27 Jan	LATAM Airlines Group
31 Dec - 27 Jan	LATAM Airlines Group
25 Dec - 22 Jan	Air Canada
03 Dec - 06 Dec	Azul Airlines
01 Dec - 15 Dec	LATAM Airlines Group
30 Dec - 20 Jan	Air Canada
28 Dec - 28 Jan	LATAM Airlines Group
03 Dec - 20 Jan	Azul Airlines
08 Dec - 20 Jan	Air Canada
02 Dec - 19 Jan	Azul Airlines
03 Dec - 15 Jan	Azul Airlines
31 Dec - 30 Jan	Azul Airlines
03 Dec - 31 Dec	Azul Airlines
01 Dec - 17 Dec	Azul Airlines
01 Dec - 31 Dec	Azul Airlines
01 Dec - 23 Dec	Air Canada
02 Dec - 31 Dec	easyJet
01 Dec - 30 Dec	Transavia France
13 Dec - 24 Dec	TAP

Also check the deals for one-way flights from Lisbon to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Lisbon to Santiago in December from $721

Return flights