AirHint found the following cheapest return flights from Lisbon (LIS) to Sao Tome (TMS) in December 2025 (see full year).

Return flights

04 Dec - 10 Dec	TAAG Angola Airlines
21 Dec - 26 Dec	TAAG Angola Airlines
06 Dec - 27 Dec	TAP	direct
18 Dec - 12 Jan	TAAG Angola Airlines
10 Dec - 27 Dec	TAP
07 Dec - 14 Dec	TAAG Angola Airlines
09 Dec - 21 Dec	TAAG Angola Airlines
03 Dec - 07 Dec	TAP
02 Dec - 13 Dec	TAAG Angola Airlines
04 Dec - 13 Dec	TAAG Angola Airlines
06 Dec - 17 Dec	TAP
10 Dec - 07 Jan	TAP
13 Dec - 10 Jan	TAP	direct
12 Dec - 10 Jan	TAP
24 Dec - 11 Jan	TAP
21 Dec - 14 Jan	TAP
23 Dec - 11 Jan	TAAG Angola Airlines
21 Dec - 12 Jan	TAP
27 Dec - 10 Jan	Euroatlantic Airways Charter	direct
20 Dec - 10 Jan	Euroatlantic Airways Charter	direct

Also check the deals for one-way flights from Lisbon to Sao Tome in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Lisbon to Sao Tome in December from $543

Return flights