AirHint found the following cheapest return flights from Madrid (MAD) to Sao Paulo (GRU) in October 2025 (see full year).

Return flights

02 Oct - 18 Oct	Delta
23 Oct - 30 Oct	Delta
23 Oct - 14 Nov	Delta
24 Oct - 31 Oct	Royal Air Maroc
31 Oct - 21 Nov	Royal Air Maroc
13 Oct - 27 Oct	TAP
25 Oct - 08 Nov	Delta
25 Oct - 17 Nov	Delta
08 Oct - 23 Oct	Delta
09 Oct - 19 Oct	Delta
06 Oct - 28 Oct	Delta
06 Oct - 23 Oct	Delta
03 Oct - 30 Oct	Delta
03 Oct - 18 Oct	Delta
31 Oct - 14 Nov	Royal Air Maroc
31 Oct - 07 Nov	Royal Air Maroc
22 Oct - 19 Nov	Delta
06 Oct - 02 Nov	TAP
26 Oct - 05 Nov	Royal Air Maroc
24 Oct - 02 Nov	Royal Air Maroc

Also check the deals for one-way flights from Madrid to Sao Paulo in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Sao Paulo in October from $722

Return flights