AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in October 2025 (see full year).

Return flights

02 Oct - 30 Oct	Delta
02 Oct - 27 Oct	Delta
09 Oct - 19 Oct	Delta
28 Oct - 09 Nov	Delta
27 Oct - 23 Nov	Delta
26 Oct - 02 Nov	Delta
26 Oct - 26 Nov	Delta
27 Oct - 14 Nov	Delta
29 Oct - 15 Nov	Delta
09 Oct - 18 Nov	Delta
27 Oct - 12 Nov	Delta
09 Oct - 27 Oct	Delta
16 Oct - 26 Oct	Delta
09 Oct - 26 Oct	Delta
07 Oct - 21 Oct	Delta
07 Oct - 26 Oct	Delta
16 Oct - 26 Nov	Delta
06 Oct - 24 Oct	Delta
06 Oct - 20 Oct	Delta
31 Oct - 28 Nov	Delta

Also check the deals for one-way flights from Madrid to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in October from $821

Return flights