Cheapest return flights from Madrid to Santiago in October from $951

Best time to book flights for Madrid (MAD) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in October 2025 (see full year).

Return flights

16 Oct - 26 Oct Delta
16 Oct - 05 Nov Delta
16 Oct - 13 Nov Delta
30 Oct - 15 Nov TAP
07 Oct - 14 Oct TAP
01 Oct - 23 Oct Azul Airlines
29 Oct - 16 Nov TAP
06 Oct - 19 Oct TAP
06 Oct - 27 Oct Ryanair
23 Oct - 31 Oct Ryanair
06 Oct - 16 Oct TAP
20 Oct - 27 Oct Iberia
20 Oct - 20 Nov Iberia
20 Oct - 03 Nov Iberia
14 Oct - 23 Oct Ryanair
23 Oct - 30 Oct Ryanair
13 Oct - 02 Nov Ryanair
21 Oct - 13 Nov Delta
23 Oct - 06 Nov Iberia
27 Oct - 17 Nov Iberia

Also check the deals for one-way flights from Madrid to Santiago in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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