AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in September 2025 (see full year).

Return flights

15 Sep - 28 Sep	Delta
17 Sep - 28 Sep	Delta
08 Sep - 28 Sep	Delta
03 Sep - 19 Oct	Delta
15 Sep - 15 Oct	Delta
16 Sep - 07 Oct	Delta
25 Sep - 16 Oct	Delta
17 Sep - 22 Oct	Delta
11 Sep - 07 Oct	Delta
15 Sep - 24 Sep	Delta
11 Sep - 24 Sep	Delta
16 Sep - 24 Sep	Delta
09 Sep - 24 Sep	Delta
08 Sep - 24 Sep	Delta
04 Sep - 18 Oct	Delta
15 Sep - 01 Oct	Delta
13 Sep - 22 Sep	Air Canada
25 Sep - 14 Oct	Delta
13 Sep - 12 Oct	Air Canada
05 Sep - 22 Sep	Air Canada

Also check the deals for one-way flights from Madrid to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in September from $819

Return flights