AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in September 2025 (see full year).

Return flights

10 Sep - 28 Sep	Delta
03 Sep - 28 Sep	Delta
18 Sep - 28 Sep	Delta
17 Sep - 28 Sep	Delta
13 Sep - 28 Sep	Delta
08 Sep - 15 Sep	Delta
04 Sep - 15 Sep	Delta
11 Sep - 28 Sep	Delta
12 Sep - 28 Sep	Delta
17 Sep - 20 Oct	Delta
17 Sep - 01 Oct	Delta
17 Sep - 22 Oct	Delta
24 Sep - 06 Oct	Delta
24 Sep - 01 Oct	Delta
15 Sep - 01 Oct	Delta
12 Sep - 17 Oct	Delta
15 Sep - 06 Oct	Delta
08 Sep - 04 Oct	Delta
10 Sep - 01 Oct	Delta
08 Sep - 21 Sep	Delta

Also check the deals for one-way flights from Madrid to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in September from $821

Return flights