AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in December 2025 (see full year).

Return flights

01 Dec - 11 Dec	Avianca
08 Dec - 15 Dec	Avianca
24 Dec - 24 Jan	Avianca
26 Dec - 26 Jan	Avianca
03 Dec - 25 Dec	Avianca
01 Dec - 01 Jan	Avianca
08 Dec - 01 Jan	Avianca
26 Dec - 26 Jan	Iberia	direct
03 Dec - 01 Jan	Avianca
03 Dec - 25 Dec	Iberia	direct
10 Dec - 17 Dec	Plus Ultra Lineas Aereas
01 Dec - 11 Dec	Air Europa	direct
17 Dec - 29 Dec	Iberia	direct
10 Dec - 20 Dec	Iberia	direct
15 Dec - 18 Jan	LATAM Airlines Group
29 Dec - 11 Jan	Plus Ultra Lineas Aereas
02 Dec - 02 Jan	Avianca
10 Dec - 13 Jan	Plus Ultra Lineas Aereas
21 Dec - 29 Dec	Avianca
05 Dec - 27 Dec	Iberia	direct

Also check the deals for one-way flights from Madrid to Santa Cruz in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in December from $988

Return flights