AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in December 2025 (see full year).

Return flights

31 Dec - 31 Jan	Avianca
28 Dec - 21 Jan	Avianca
24 Dec - 24 Jan	Avianca
10 Dec - 23 Dec	LATAM Airlines Group
01 Dec - 01 Jan	Avianca
01 Dec - 05 Dec	Avianca
01 Dec - 21 Dec	LATAM Airlines Group
31 Dec - 31 Jan	Air Europa	direct
05 Dec - 27 Dec	Avianca
22 Dec - 22 Jan	Avianca
09 Dec - 22 Dec	Avianca
31 Dec - 12 Jan	Iberia	direct
10 Dec - 23 Dec	Air Europa	direct
10 Dec - 10 Jan	LATAM Airlines Group
22 Dec - 23 Dec	Air Europa	direct
24 Dec - 24 Jan	Air Europa	direct
19 Dec - 18 Jan	LATAM Airlines Group
22 Dec - 29 Dec	Avianca
19 Dec - 26 Dec	LATAM Airlines Group
22 Dec - 29 Dec	Air Europa	direct

Also check the deals for one-way flights from Madrid to Santa Cruz in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in December from $930

Return flights