AirHint found the following cheapest return flights from Rio Negro (MDE) to Sao Paulo (GRU) in December 2025 (see full year).

Return flights

03 Dec - 11 Dec	GOL Linhas Aéreas
09 Dec - 12 Dec	Avianca
29 Dec - 21 Jan	Avianca
19 Dec - 03 Jan	Avianca
29 Dec - 17 Jan	Avianca
27 Dec - 17 Jan	Avianca
28 Dec - 17 Jan	Avianca
30 Dec - 07 Jan	GOL Linhas Aéreas
30 Dec - 06 Jan	GOL Linhas Aéreas
20 Dec - 02 Jan	GOL Linhas Aéreas
26 Dec - 06 Jan	GOL Linhas Aéreas
09 Dec - 14 Dec	Avianca
28 Dec - 08 Jan	Avianca
01 Dec - 13 Dec	Avianca
15 Dec - 19 Dec	GOL Linhas Aéreas

Also check the deals for one-way flights from Rio Negro to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Sao Paulo in December from $411

Return flights