AirHint found the following cheapest return flights from Rio Negro (MDE) to Santiago (SCL) in December 2025 (see full year).

Return flights

15 Dec - 30 Dec	JetSmart
12 Dec - 30 Dec	JetSmart
12 Dec - 30 Dec	JetSmart	direct
08 Dec - 13 Dec	JetSmart
14 Dec - 30 Dec	JetSmart	direct
09 Dec - 13 Dec	JetSmart
09 Dec - 30 Dec	JetSmart
08 Dec - 12 Dec	JetSmart
15 Dec - 30 Dec	JetSmart	direct
15 Dec - 19 Dec	JetSmart
17 Dec - 07 Jan	JetSmart
21 Dec - 07 Jan	JetSmart	direct
22 Dec - 07 Jan	JetSmart	direct
15 Dec - 02 Jan	JetSmart
12 Dec - 02 Jan	JetSmart
31 Dec - 14 Jan	JetSmart
14 Dec - 02 Jan	JetSmart
31 Dec - 07 Jan	JetSmart
12 Dec - 02 Jan	JetSmart	direct
28 Dec - 14 Jan	JetSmart	direct

Also check the deals for one-way flights from Rio Negro to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Santiago in December from $276

Return flights