AirHint found the following cheapest return flights from Rio Negro (MDE) to Santiago (SCL) in December 2025 (see full year).

Return flights

29 Dec - 09 Jan	JetSmart
29 Dec - 17 Jan	JetSmart
29 Dec - 01 Jan	JetSmart
29 Dec - 08 Jan	JetSmart
29 Dec - 15 Jan	JetSmart
29 Dec - 13 Jan	JetSmart
29 Dec - 18 Jan	JetSmart
13 Dec - 01 Jan	JetSmart
08 Dec - 11 Dec	JetSmart
08 Dec - 26 Dec	JetSmart
29 Dec - 19 Jan	JetSmart
08 Dec - 12 Dec	JetSmart
05 Dec - 09 Dec	JetSmart
08 Dec - 25 Dec	JetSmart
04 Dec - 09 Dec	JetSmart
07 Dec - 09 Dec	JetSmart
13 Dec - 26 Dec	JetSmart
18 Dec - 01 Jan	JetSmart
08 Dec - 09 Dec	JetSmart
01 Dec - 09 Dec	JetSmart

Also check the deals for one-way flights from Rio Negro to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Rio Negro to Santiago in December from $341

Return flights