AirHint found the following cheapest return flights from Melbourne (MEL) to Santiago (SCL) in September 2025 (see full year).

Return flights

04 Sep - 09 Sep	LATAM Airlines Group
03 Sep - 19 Oct	LATAM Airlines Group	direct
01 Sep - 07 Sep	LATAM Airlines Group
11 Sep - 18 Sep	Qantas
01 Sep - 08 Sep	Cathay Pacific
10 Sep - 10 Oct	LATAM Airlines Group	direct
01 Sep - 14 Sep	Qantas
01 Sep - 11 Sep	Qantas
04 Sep - 04 Sep	Qantas
04 Sep - 25 Sep	Qantas
11 Sep - 25 Sep	Qantas
15 Sep - 21 Sep	Qantas
05 Sep - 21 Oct	Qantas
13 Sep - 03 Oct	Qantas	direct
09 Sep - 14 Oct	Qantas
17 Sep - 11 Oct	LATAM Airlines Group

Also check the deals for one-way flights from Melbourne to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Melbourne to Santiago in September from $1377

Return flights