Cheapest return flights from Mexico City to Santiago in October from $371

Best time to book flights for Mexico City (MEX) to Santiago (SCL) flights at AirHint

AirHint found the following cheapest return flights from Mexico City (MEX) to Santiago (SCL) in October 2025 (see full year).

Return flights

16 Oct - 22 Oct Arajet
02 Oct - 08 Oct Arajet
30 Oct - 05 Nov Arajet
23 Oct - 29 Oct Arajet
07 Oct - 22 Oct Arajet
14 Oct - 29 Oct Arajet
07 Oct - 28 Oct LATAM Airlines Group direct
02 Oct - 16 Oct Copa
16 Oct - 26 Oct Copa
07 Oct - 14 Oct Copa
08 Oct - 24 Oct Copa
20 Oct - 03 Nov Copa
30 Oct - 07 Nov Copa
23 Oct - 04 Nov Copa
20 Oct - 03 Nov LATAM Airlines Group direct
30 Oct - 07 Nov Aeromexico direct

Also check the deals for one-way flights from Mexico City to Santiago in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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