Cheapest return flights from Chicago to Santiago in December from $721

AirHint found the following cheapest return flights from Chicago (ORD) to Santiago (SCL) in December 2025 (see full year).

Return flights

11 Dec - 18 Dec Spirit Airlines
12 Dec - 19 Dec Spirit Airlines
18 Dec - 09 Jan Copa
26 Dec - 04 Jan Frontier Airlines
22 Dec - 31 Dec American Airlines
22 Dec - 03 Jan Spirit Airlines
19 Dec - 02 Jan Frontier Airlines

Also check the deals for one-way flights from Chicago to Santiago in December.

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