AirHint found the following cheapest return flights from Palermo (PMO) to Prague (PRG) in December 2025 (see full year).

Return flights

02 Dec - 06 Dec	easyJet
02 Dec - 04 Dec	easyJet
01 Dec - 06 Dec	easyJet
01 Dec - 03 Dec	easyJet
13 Dec - 15 Dec	easyJet
11 Dec - 15 Dec	easyJet
01 Dec - 04 Dec	easyJet
10 Dec - 13 Dec	easyJet
12 Dec - 15 Dec	easyJet
10 Dec - 14 Dec	Ryanair
26 Dec - 01 Jan	easyJet
27 Dec - 02 Jan	Ryanair
27 Dec - 03 Jan	Ryanair
31 Dec - 04 Jan	Ryanair
31 Dec - 05 Jan	Ryanair
28 Dec - 02 Jan	Lufthansa
30 Dec - 05 Jan	Ryanair
30 Dec - 04 Jan	Ryanair
28 Dec - 03 Jan	Aeroitalia
29 Dec - 03 Jan	Ryanair

Also check the deals for one-way flights from Palermo to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Prague

Cheap car rent in Prague

Cheapest return flights from Palermo to Prague in December from $131

Return flights