AirHint found the following cheapest return flights from Palermo (PMO) to Prague (PRG) in December 2025 (see full year).

Return flights

02 Dec - 06 Dec	Ryanair
16 Dec - 19 Dec	Ryanair
01 Dec - 06 Dec	Volotea
04 Dec - 06 Dec	Ryanair
15 Dec - 19 Dec	Volotea
01 Dec - 01 Jan	Volotea
27 Dec - 01 Jan	Ryanair
09 Dec - 13 Dec	Ryanair
15 Dec - 18 Dec	easyJet
13 Dec - 15 Dec	Ryanair
07 Dec - 13 Dec	Ryanair
07 Dec - 11 Dec	easyJet
31 Dec - 01 Jan	Ryanair
27 Dec - 04 Jan	Ryanair
31 Dec - 04 Jan	Ryanair
29 Dec - 01 Jan	Ryanair
26 Dec - 01 Jan	Ryanair
28 Dec - 01 Jan	Ryanair
31 Dec - 05 Jan	Ryanair
31 Dec - 02 Jan	Ryanair

Also check the deals for one-way flights from Palermo to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Palermo to Prague in December from $147

Return flights