AirHint found the following cheapest return flights from Palermo (PMO) to Prague (PRG) in December 2025 (see full year).

Return flights

15 Dec - 18 Dec	Ryanair
22 Dec - 04 Jan	Volotea
23 Dec - 03 Jan	Ryanair
22 Dec - 03 Jan	Ryanair
25 Dec - 31 Dec	SWISS
25 Dec - 01 Jan	SWISS
27 Dec - 04 Jan	Ryanair
16 Dec - 18 Dec	Ryanair
27 Dec - 31 Dec	Ryanair
21 Dec - 31 Dec	SWISS
23 Dec - 27 Dec	Ryanair
27 Dec - 01 Jan	Ryanair
17 Dec - 20 Dec	Ryanair
15 Dec - 20 Dec	Ryanair
18 Dec - 20 Dec	Ryanair
20 Dec - 27 Dec	Ryanair
29 Dec - 04 Jan	Ryanair
27 Dec - 03 Jan	Ryanair
29 Dec - 01 Jan	Ryanair
24 Dec - 03 Jan	Ryanair

Also check the deals for one-way flights from Palermo to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Prague

Cheap car rent in Prague

Cheapest return flights from Palermo to Prague in December from $168

Return flights