Cheapest return flights from Santiago to Guayaquil in October from $314

AirHint found the following cheapest return flights from Santiago (SCL) to Guayaquil (GYE) in October 2025 (see full year).

Return flights

22 Oct - 27 Oct LATAM Airlines Group
18 Oct - 31 Oct Copa

Also check the deals for one-way flights from Santiago to Guayaquil in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Guayaquil

Cheap car rent in Guayaquil

Feel free to contact us with any feedback or request another flight research.