AirHint found the following cheapest return flights from Santo Domingo (SDQ) to Madrid (MAD) in September 2025 (see full year).

Return flights

20 Sep - 30 Sep	Arajet
20 Sep - 26 Oct	Arajet
12 Sep - 16 Sep	Spirit Airlines
26 Sep - 23 Oct	Arajet
15 Sep - 23 Sep	jetBlue
10 Sep - 25 Sep	Spirit Airlines
21 Sep - 19 Oct	Spirit Airlines
23 Sep - 06 Oct	Air Europa	direct
18 Sep - 25 Sep	jetBlue
16 Sep - 18 Sep	jetBlue
04 Sep - 28 Sep	Spirit Airlines
04 Sep - 25 Sep	Spirit Airlines
04 Sep - 11 Sep	Spirit Airlines
21 Sep - 12 Oct	Spirit Airlines
26 Sep - 23 Oct	Air Europa	direct
22 Sep - 09 Oct	Air Europa	direct
15 Sep - 22 Sep	jetBlue
24 Sep - 31 Oct	Air Europa	direct
24 Sep - 30 Oct	Air Europa	direct
28 Sep - 07 Oct	Air Europa	direct

Also check the deals for one-way flights from Santo Domingo to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Madrid

Cheap car rent in Madrid

Cheapest return flights from Santo Domingo to Madrid in September from $660

Return flights