AirHint found the following cheapest return flights from Santo Domingo (SDQ) to Madrid (MAD) in September 2025 (see full year).

Return flights

18 Sep - 25 Sep	WORLD2FLY	direct
15 Sep - 28 Sep	WORLD2FLY	direct
07 Sep - 14 Sep	Arajet
23 Sep - 04 Oct	Arajet
25 Sep - 12 Oct	WORLD2FLY	direct
04 Sep - 14 Sep	Arajet
21 Sep - 12 Oct	WORLD2FLY	direct
28 Sep - 05 Oct	WORLD2FLY	direct
28 Sep - 12 Oct	WORLD2FLY	direct
25 Sep - 10 Oct	Air Europa	direct
26 Sep - 03 Oct	Air Europa	direct
27 Sep - 23 Oct	Iberia	direct
23 Sep - 11 Oct	Iberia	direct
04 Sep - 14 Sep	WORLD2FLY	direct
02 Sep - 06 Sep	Arajet
02 Sep - 23 Sep	Arajet
21 Sep - 11 Oct	Iberia	direct
01 Sep - 11 Sep	WORLD2FLY	direct
04 Sep - 30 Sep	KLM
06 Sep - 20 Sep	Arajet

Also check the deals for one-way flights from Santo Domingo to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santo Domingo to Madrid in September from $704

Return flights